Postdoctoral Research Associate
University of Oxford -Department of Biochemistry
South Parks Road, Oxford
Grade 7: £29,837 - £36,661 p.a.
We are seeking to appoint a Postdoctoral Research Associate to develop the work of Mark Howarth’s group in creating a new class of protein interaction. SpyTag/SpyCatcher is a genetically-encoded system where protein and peptide partners form an irreversible covalent bond. SpyTag/SpyCatcher is starting to be applied around the world in diverse areas of basic research and biotechnology. Library-based and rational design will be used to improve this technology in terms of speed of reaction, sensitivity, and application in diverse cellular environments. The researcher will then be able to test and refine the performance of these evolved tools in a range of applications, including generating new kinds of protein architectures, particularly using antibodies. One application of such architectures will be for the improved magnetic capture of cancer cells. Such approaches will enhance our understanding of cancer biology and also in the long-term enable optimal therapy to be chosen as the cancer evolves. We will provide training in unfamiliar methods.
Applicants should possess, or expect to obtain soon, a PhD in Biochemistry, Cell Biology or a related area. They should be familiar with PCR, ligation, transformation, site-directed mutagenesis, recombinant protein expression, and protein chromatography and they should have applied these in their research.
This full-time post is funded by European Research Council (ERC) for up to 2 years in the first instance and is based at the Department of Biochemistry, South Parks Road, Oxford.
The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available.
For further general information phone 01865 613204, quoting reference number BR/595.
The closing date for applications is 12.00 midday on Wednesday 19 March 2014, with interviews for shortlisted candidates as soon as possible thereafter.